Article

Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations

2023-04-14

Abstract excerpt

Available genetically-defined cancer models are limited in genotypic and phenotypic complexity and underrepresent the heterogeneity of human cancer. Herein, we describe a combinatorial genetic strategy applied to an organoid transformation assay to rapidly generate diverse, clinically relevant bladder and prostate cancer models. Importantly, the clonal architecture of the resultant tumors can be resolved using sin...

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Literature Corpus work: df2d3d00-0b0d-5472-88fb-e3c2db903a01
DOI: 10.1101/2023.04.12.536652

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