Article
Patient derived organoids to model rare prostate cancer phenotypes.
Nature communications - 19 Jun 2018
Puca Loredana, Bareja Rohan, Prandi Davide, Shaw Reid, Benelli Matteo, Karthaus Wouter R, Hess Judy, Sigouros Michael, Donoghue Adam, Kossai Myriam, Gao Dong, Cyrta Joanna, Sailer Verena, Vosoughi Aram, Pauli Chantal, Churakova Yelena, Cheung Cynthia, Deonarine Lesa Dayal, McNary Terra J, Rosati Rachele, Tagawa Scott T, Nanus David M, Mosquera Juan Miguel, Sawyers Charles L, Chen Yu, Inghirami Giorgio, Rao Rema A, Grandori Carla, Elemento Olivier, Sboner Andrea, Demichelis Francesca, Rubin Mark A, Beltran Himisha
Abstract excerpt
A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive histologic variant of prostate cancer that may arise de novo or as a mechanism of treatment resistance in patients with pre-existing castration-resistant prostate cancer. There are few available models to study neuroendocrine prostate cancer. Here, we report the...
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