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Article

A combinatorial genetic strategy for exploring complex genotype-phenotype associations in cancer.

Nature genetics - 1 Mar 2024

Li Shan, Wong Alicia, Sun Huiyun, Bhatia Vipul, Javier Gerardo, Jana Sujata, Wu Qian, Montgomery Robert B, Wright Jonathan L, Lam Hung-Ming, Hsieh Andrew C, Faltas Bishoy M, Haffner Michael C, Lee John K

Abstract excerpt

Available genetically defined cancer models are limited in genotypic and phenotypic complexity and underrepresent the heterogeneity of human cancer. Here, we describe a combinatorial genetic strategy applied to an organoid transformation assay to rapidly generate diverse, clinically relevant bladder and prostate cancer models. Importantly, the clonal architecture of the resultant tumors can be resolved using...

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Identifiers

PMID: 38424461
DOI: 10.1038/s41588-024-01674-1
PMCID: PMC10937382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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