Article

Brain-region-aware genetic prioritization separates Alzheimer disease risk from APOE-sensitive β-amyloid burden in public genetic and expression quantitative trait locus resources

2026-07-01

Abstract excerpt

<title>Abstract</title> <p> Background Genome-wide studies of Alzheimer disease (AD) often prioritize case-control risk loci, but disease risk and β-amyloid burden capture different biology. In the chr19 <italic>APOE</italic> region, nearby variants can also inflate non- <italic>APOE</italic> target claims. Methods We integrated one public AD-risk GWAS and two public β-amyloid GWAS with blood, GTEx v10 who...

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Literature Corpus work: df270025-cd96-502c-8f79-004254dc17bb
DOI: 10.21203/rs.3.rs-10006828/v1

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