Article

The <i>Salmonella</i> LysR family regulator, RipR, activates the SPI-13 encoded itaconate degradation cluster

2019-05-24

Abstract excerpt

Itaconate is a dicarboxylic acid that inhibits the isocitrate lyase enzyme of the bacterial glyoxylate shunt. Activated macrophages have been shown to produce itaconate, suggesting that these immune cells may employ this metabolite as a weapon against invading bacteria. Here we demonstrate that, in vitro , itaconate can exhibit bactericidal effects under acidic conditions similar to the pH of a macrophage phagoso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df1975e1-cde2-5a1d-b7a0-c62c8a202546
DOI: 10.1101/648865

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The <i>Salmonella</i> LysR family regulator, RipR, activates the SPI-13 encoded itaconate degradation clusterDOI 10.1101/648865Read

Intracellular <i>Salmonella</i> Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular <i>S</i> . TyphimuriumSemantic proximity Read

The quorum-sensing lexicon of <i>Salmonella</i> ameliorates acid stress in the host by a non-canonical mechanismSemantic proximity Read

Itaconate family-based host-directed therapeutics for infectionsSemantic proximity Read

Indole Sensing Regulator (IsrR) Promotes Virulence Gene Expression in Enteric PathogensSemantic proximity Read

<i>Irg1</i> expression in myeloid cells prevents immunopathology during <i>M. tuberculosis</i> infectionSemantic proximity Read

Itaconate utilisation by the human pathogen <i>Pseudomonas aeruginosa</i> requires uptake via the IctPQM TRAP transporterSemantic proximity Read

<i>Listeria monocytogenes</i> TcyKLMN cystine/cysteine transporter facilitates glutathione synthesis and virulence gene expressionSemantic proximity Read

Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase.Semantic proximity Read

Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. TyphimuriumSemantic proximity Read

The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of <i>Leptospira interrogans</i>Semantic proximity Read

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in <i>M. tuberculosis</i> host defenseSemantic proximity Read

Methylthioadenosine reduces host inflammatory response by suppressing <i>Salmonella</i> virulenceSemantic proximity Read