Article

Itaconate utilisation by the human pathogen <i>Pseudomonas aeruginosa</i> requires uptake via the IctPQM TRAP transporter

2025-04-01

Abstract excerpt

Pseudomonas aeruginosa PA01 is one of the major causes of disease persistence and mortality in patients with lung pathologies, relying on various host metabolites as carbon and energy sources for growth. The ict-ich-ccl operon ( pa0878, pa0882, pa0883 ) in PAO1 is required for growth on the host molecule itaconate, a C 5 -dicarboxylate. However, it is not known how itaconate is taken up into P. aeruginosa . He...

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Literature Corpus work: ce66d41a-20ef-52d5-94e0-1926067cc0ba
DOI: 10.1101/2025.04.01.646390

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