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Article

Indole Sensing Regulator (IsrR) Promotes Virulence Gene Expression in Enteric Pathogens

2 Aug 2022

Abstract excerpt

Enteric pathogens sense the complex intestinal chemistry to find a suitable colonization niche. The microbiota plays an important part in shaping this chemistry. Here we show that the abundant microbiota-derived exogenous signal indole impacts host-pathogen interactions by allowing enteric pathogens to discriminate between the luminal environment, where expression of virulence genes is an unnecessary energy...

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Identifiers

PMID: 35916401
DOI: 10.1128/mbio.01939-22

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