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<i>Listeria monocytogenes</i> TcyKLMN cystine/cysteine transporter facilitates glutathione synthesis and virulence gene expression

2021-09-08

Abstract excerpt

Listeria monocytogenes ( Lm ) is a saprophyte and a human intracellular pathogen. Upon invasion into mammalian cells, it senses multiple metabolic and environmental signals that collectively trigger its transition to the pathogenic state. One of these signals is the tripeptide glutathione, which acts as an allosteric activator of Lm ’s master virulence regulator, PrfA. While glutathione synthesis by Lm was show...

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Identifiers and source

Literature Corpus work
b2333371-ffd8-5b96-ba81-da7c231c91b0
DOI
10.1101/2021.09.07.459368
Open publication

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