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Article

Association Between Genetic Polymorphisms and Steady-State Plasma Concentration of Warfarin Optical Isomers

2020-03-25

Abstract excerpt

<title>Abstract</title> <p>Background We evaluated the effects of CYP2C19*2, CYP2C9*3, VKORC1 A1639G, CYP4F2, and MDR1 C3435T gene polymorphisms on the plasma concentrations of R- and S-warfarin enantiomers at the same dose.Methods The plasma concentrations of R- and S-warfarin were determined by ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) in 136 patients. The PCR-RFLP genotyping...

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Literature Corpus work
df124f08-64a4-5008-8607-638bcef216df
DOI
10.21203/rs.3.rs-18925/v1
Open publication

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Association Between Genetic Polymorphisms and Steady-State Plasma Concentration of Warfarin Optical IsomersDOI 10.21203/rs.3.rs-18925/v1
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