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Influence of CYP2C9 Polymorphisms on Plasma Concentration of Warfarin and 7-Hydroxy Warfarin in South Indian Patients.

Current drug metabolism - 1 Jan 2021

Kumar Dhakchinamoorthi Krishna, Uppugunduri Chakradhara Rao Satyanarayana, Shewade Deepak Gopal, Chandran B V Sai, Adithan Chandrasekaran

Abstract excerpt

BACKGROUND: Warfarin is primarily metabolized by cytochrome P450 2C9 (CYP2C9) enzyme, which is encoded by the CYP2C9 gene. CYP2C9*2 and CYP2C9*3 variants significantly influence warfarin metabolism and subsequently the required dose of warfarin. OBJECTIVES: The current retrospective study was aimed to determine the influence of CYP2C9 variants on warfarin metabolic ratio (MR, warfarin/7-hydroxy warfarin) and...

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PMID: 34802403
DOI: 10.2174/1389200222666211119104412

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