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Article

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2018

Haraszti Reka Agnes, Miller Rachael, Didiot Marie-Cecile, Biscans Annabelle, Alterman Julia F, Hassler Matthew R, Roux Loic, Echeverria Dimas, Sapp Ellen, DiFiglia Marian, Aronin Neil, Khvorova Anastasia

Abstract excerpt

Extracellular vesicles are promising delivery vesicles for therapeutic RNAs. Small interfering RNA (siRNA) conjugation to cholesterol enables efficient and reproducible loading of extracellular vesicles with the therapeutic cargo. siRNAs are typically chemically modified to fit an application. However, siRNA chemical modification pattern has not been specifically optimized for extracellular vesicle-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29937418
DOI: 10.1016/j.ymthe.2018.05.024
PMCID: PMC6094392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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