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Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

26 Oct 2023

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from treatment with hypomethylating agents (HMAs), but no predictive biomarkers for therapy response exist. Here, we investigated whether unbiased genome-wide assessment of pre-treatment DNA-methylation...

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PMID: 37885041
DOI: 10.1186/s13148-023-01580-z

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