Article

Predicting gene expression changes upon epigenomic drug treatment

2023-07-23

Abstract excerpt

<h4>Background</h4> Tumors are characterized by global changes in epigenetic changes such as DNA methylation and histone modifications that are functionally linked to tumor progression. Accordingly, several drugs targeting the epigenome have been proposed for cancer therapy, notably, histone deacetylase inhibitors (HDACi) such as Vorinostatis and DNA methyltransferase inhibitors (DNMTi) such as Zebularine . How...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84800a68-d468-5018-9cd7-a2269b46d843
DOI: 10.1101/2023.07.20.549955

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predicting gene expression changes upon epigenomic drug treatmentDOI 10.1101/2023.07.20.549955Read

Predicting gene expression changes upon epigenomic drug treatmentSemantic proximity Read

Genomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers.Semantic proximity Read

Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer.Semantic proximity Read

Epigenome-Based Drug Repositioning in Acute Myeloid LeukemiaSemantic proximity Read

Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signaturesSemantic proximity Read

BioXNet: a biologically inspired neural network for deciphering anti-cancer drug response in precision medicineSemantic proximity Read

Predicting drug sensitivity of cancer cells based on DNA methylation levelsSemantic proximity Read

Prediction of drug targets for specific diseases leveraging gene perturbation data: A machine learning approachSemantic proximity Read

Gene isoforms as expression-based biomarkers predictive of drug response <i>in vitro</i>Semantic proximity Read

Predicting response to epigenetic therapySemantic proximity Read

Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimenSemantic proximity Read

Loci specific epigenetic drug sensitivitySemantic proximity Read