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Article

Transcriptional data: a new gateway to drug repositioning?

Drug discovery today - 1 Apr 2013

Iorio Francesco, Rittman Timothy, Ge Hong, Menden Michael, Saez-Rodriguez Julio

Abstract excerpt

Recent advances in computational biology suggest that any perturbation to the transcriptional programme of the cell can be summarised by a proper 'signature': a set of genes combined with a pattern of expression. Therefore, it should be possible to generate proxies of clinicopathological phenotypes and drug effects through signatures acquired via DNA microarray technology. Gene expression signatures have recently...

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Identifiers

PMID: 22897878
DOI: 10.1016/j.drudis.2012.07.014
PMCID: PMC3625109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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