Article

Predicting gene expression changes upon epigenomic drug treatment

2025-05-02

Abstract excerpt

Background Tumors are characterized by global changes in epigenetic modifications such as DNA methylation and histone modifications that are functionally linked to tumor progression. Accordingly, several drugs targeting the epigenome have been proposed for cancer therapy, notably, histone deacetylase inhibitors (HDACi) such as vorinostat and DNA methyltransferase inhibitors (DNMTi) such as zebularine. However, a f...

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Literature Corpus work: 88252dfc-0287-5cb4-9d4e-451acc3f9886
DOI: 10.12688/f1000research.140273.3

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