Article
The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response
9 Mar 2022
Abstract excerpt
A long-standing practice in the treatment of cancer is that of hitting hard with the maximum tolerated dose to eradicate tumors. This continuous therapy, however, selects for resistant cells, leading to the failure of the treatment. A different type of treatment strategy, adaptive therapy, has recently been shown to have a degree of success in both preclinical xenograft experiments and clinical trials. Adaptive...
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