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Article

Stochastic modeling of drug resistance in cancer.

Journal of theoretical biology - 7 Apr 2006

Komarova Natalia

Abstract excerpt

One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. Employing multi-drug therapeutic strategies is a promising way to prevent resistance and improve the chances of treatment success. We formulate and analyse a stochastic model for multi-drug resistance and investigate the dependence of treatment outcomes on the initial tumor load, mutation rates...

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Identifiers

PMID: 16194548
DOI: 10.1016/j.jtbi.2005.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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