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Long-read sequencing reveals telomere inheritance patterns from human trios

2025-10-07

Abstract excerpt

Telomeres are essential for maintaining genomic integrity and are associated with cellular aging and disease, yet the factors influencing their inheritance across generations remain poorly understood. Leveraging PacBio HiFi long-read sequencing and 75 parent-offspring trios (n = 225) from the Genomic Answers for Kids program, we analyzed individual telomeres across chromosomes and their inheritance. Telomere lengt...

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Literature Corpus work
decfe81c-4088-5b49-8c60-e2e541662a8a
DOI
10.1101/2025.10.07.680721
Open publication

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Long-read sequencing reveals telomere inheritance patterns from human triosDOI 10.1101/2025.10.07.680721
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