Article

Defining the molecular determinants of titin kinase by analysing distantly evolved fish orthologues

2025-08-04

Abstract excerpt

Titin kinase (TK) is a pseudokinase specific to the striated muscle of vertebrates. Embedded within the contractile sarcomere and flanked by extensible regulatory tails, TK is thought to sense mechanical signals arising from muscle function. Studies on TK to date have focused narrowly on the human representative. To investigate if a pseudokinase character is a hallmark of TK, we have studied sequences of distantly...

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Literature Corpus work: decb16d1-fd57-52db-88c3-fa9467fecca4
DOI: 10.1101/2025.08.04.668337

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