Article

Titin role in muscle homeostasis : the kinase domain

2014-01-01

Abstract excerpt

The giant muscle protein titin is a central player in cardiovascular health and disease. Titin molecules spanning half of the sarcomere form a filament system in striated muscles. The titin filament is not only an essential structural component of sarcomere, but also plays a central role in myofibril signaling through its kinase domain (TK) and numerous protein ligands. Thus, not surprisingly, mutations in this mo...

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Identifiers and source

Literature Corpus work: 3ce64024-0658-5606-bf56-cf7e4ba887fb
DOI: 10.17638/00018355

Open publication

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