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Article

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Aug 2007

Granzier Henk, Radke Michael, Royal Joseph, Wu Yiming, Irving Thomas C, Gotthardt Michael, Labeit Siegfried

Abstract excerpt

Titin is a giant filamentous elastic protein that spans from the Z-disk to M-band regions of the sarcomere. The I-band region of titin is extensible and develops passive force in stretched sarcomeres. This force has been implicated as a factor involved in regulating cardiac contraction. To better...

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Identifiers

PMID: 17522126
DOI: 10.1152/ajpregu.00001.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17522126-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.PMID 17522126Read ↗

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