Article
Human WIPI β-propeller function in autophagy and neurodegeneration.
FEBS letters - 1 Jan 2024
Proikas-Cezanne Tassula, Haas Maximilian L, Pastor-Maldonado Carmen J, Schüssele David S
Abstract excerpt
The four human WIPI β-propellers, WIPI1 through WIPI4, belong to the ancient PROPPIN family and fulfill scaffold functions in the control of autophagy. In this context, WIPI β-propellers function as PI3P effectors during autophagosome formation and loss of WIPI function negatively impacts autophagy and contributes to neurodegeneration. Of particular interest are mutations in WDR45, the human gene that encodes...
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