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Article

WIPI proteins: Biological functions and related syndromes

9 Sept 2022

Abstract excerpt

WIPI ( W D-repeat protein I nteracting with P hospho I nositides) are important effectors in autophagy. These proteins bind phosphoinositides and recruit autophagy proteins. In mammals, there are four WIPI proteins: WIPI1, WIPI2, WIPI3 (WDR45B), and WIPI4 (WDR45). These proteins consist of a seven-bladed β-propeller structure. Recently, pathogenic variants in genes encoding these proteins have been recognized to...

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PMID: 36157071
DOI: 10.3389/fnmol.2022.1011918

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