Article

KMT2E haploinsufficiency manifests autistic-like phenotypes and amygdala abnormality in mice

2022-03-22

Abstract excerpt

<h4>Background: </h4> The high heritability and heterogeneity of autism spectrum disorder (ASD) are fundamentally determined by its varying genetic alterations including over 100 confident ASD-risk genes/genomic regions. Lysine Methyltransferase 2E ( KMT2E , also named MLL5 ), a distinct chromatin/transcription regulator, is recently identified as a confident ASD-risk gene with germline de novo mutations in ASD pr...

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Literature Corpus work: 4233d644-8bc5-5c98-95cd-1561f92a18e2
DOI: 10.21203/rs.3.rs-1464871/v1

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