Article

Zebrafish screen of schizophrenia risk genes reveals convergent dysregulation of cholesterol metabolism

2026-02-18

Abstract excerpt

Rare coding variants provide a tractable entry point for understanding the molecular mechanisms underlying schizophrenia risk. Here, we generated and characterized zebrafish lines with mutations in the orthologs of >20 human schizophrenia-associated genes, including eight of the top ten SCHEMA genes, genes disrupted in childhood-onset schizophrenia (COS), and genes located within recurrent copy number variants. Wh...

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Literature Corpus work: 404fcc7c-ff9b-57e1-b50e-b33cd9984680
DOI: 10.64898/2026.02.17.706411

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