Article

Studies of a siderophore-producing cyclization domain: A refined proposal of substrate binding

2022-03-19

Abstract excerpt

Nonribosomal peptide synthetase (NRPS) heterocyclization (Cy) domains generate biologically important ox-/thiazoline modifications in natural products, including in production of compounds targeting disease or siderophores that are important for bacterial pathogenicity. Cy domains share the NRPS condensation domain fold but catalyze consecutive condensation and cyclodehydration reactions via an unknown mechanism....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de9b8413-7bd3-5014-b9d9-a69433fc7d45
DOI: 10.1101/2022.03.18.483834

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Studies of a siderophore-producing cyclization domain: A refined proposal of substrate bindingDOI 10.1101/2022.03.18.483834Read

Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains.Semantic proximity Read

Evolutionary and functional analysis of an NRPS condensation domain integrates β-lactam, ᴅ-amino acid, and dehydroamino acid synthesisSemantic proximity Read

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity.Semantic proximity Read

Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis.Semantic proximity Read

Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesisSemantic proximity Read

GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discoverySemantic proximity Read

Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene SynthaseSemantic proximity Read

Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation.Semantic proximity Read

Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties.Semantic proximity Read

Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.Semantic proximity Read

Co-Occurrence of Enzyme Domains Guides the Discovery of an Oxazolone SynthetaseSemantic proximity Read

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assemblySemantic proximity Read