Article

Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene Synthase

2025-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Copalyl diphosphate synthase from Penicillium verruculosum (PvCPS) is a bifunctional class II terpene synthase containing a prenyltransferase that produces geranylgeranyl diphosphate (GGPP) and a class II cyclase that utilizes GGPP as a substrate to generate the bicyclic diterpene copalyl diphosphate. The various stereoisomers of copalyl diphosphate establish the greater family of labdane natur...

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Literature Corpus work: 25cff080-c150-5b73-80bf-9ff12b2421f4
DOI: 10.1101/2025.08.20.671325

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