Article
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties.
Biochemical and biophysical research communications - 5 Feb 2021
Gierse Robin M, Reddem Eswar R, Alhayek Alaa, Baitinger Dominik, Hamid Zhoor, Jakobi Harald, Laber Bernd, Lange Gudrun, Hirsch Anna K H, Groves Matthew R
Abstract excerpt
In this report, we describe a truncated Deinococcus radiodurans 1-deoxy-D-xylulose-5-phosphate synthase (DXS) protein that retains enzymatic activity, while slowing protein degradation and showing improved crystallization properties. With modern drug-design approaches relying heavily on the elucidation of atomic interactions of potential new drugs with their targets, the need for co-crystal structures with the...
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