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Article

Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.

Translational psychiatry - 19 Apr 2023

Hicks Emily M, Seah Carina, Cote Alanna, Marchese Shelby, Brennand Kristen J, Nestler Eric J, Girgenti Matthew J, Huckins Laura M

Abstract excerpt

Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome with genetic and environmental influences. In addition to neuroanatomical and circuit-level disturbances, dysregulation of the brain transcriptome is a key phenotypic signature of MDD. Postmortem brain gene expression data are uniquely valuable resources for identifying this signature and key genomic drivers in human depression;...

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Identifiers

PMID: 37076454
DOI: 10.1038/s41398-023-02412-7
PMCID: PMC10115809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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