Article

Noncanonical TRAIL Signaling Promotes Myeloid-Derived Suppressor Cell Abundance and Tumor Progression in Cholangiocarcinoma

2023-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Proapoptotic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling as a cause of cancer cell death is a well-established mechanism. However, TRAIL-receptor (TRAIL-R) agonists have had very limited anticancer activity in humans, challenging the concept of TRAIL as a potent anticancer agent. Herein, we demonstrate that TRAIL + cancer cells can leverage noncanonical TRAIL signa...

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Identifiers and source

Literature Corpus work: 07ab8326-a161-573a-b338-b81bdaaaca70
DOI: 10.1101/2023.05.24.541931

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