Article

Unraveling temporal dynamics of the post-mortem transcriptome in amyotrophic lateral sclerosis

2025-06-13

Abstract excerpt

Human tissue transcriptomics are crucial for understanding neurodegeneration but limited by cross-sectional post-mortem sampling, which represents end-stage disease. Subtype and Stage Inference (SuStaIn) modeling addresses these limitations by inferring temporal gene expression dynamics while also identifying potential transcriptomic subtypes. Applied to bulk RNA-seq data from post-mortem lumbar spinal cord in amy...

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Literature Corpus work: 29ac31ac-54f0-5c1f-8f45-3ba369944fec
DOI: 10.1101/2025.06.10.25329061

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