Strong and Fluctuating Sequence Constraints Drive <i>Alu_</i> Evolution

Abstract excerpt

Though Alu elements are the most common and well-studied transposable elements in the primate genome, Alu evolutionary dynamics remain poorly understood. To better understand these dynamics, we improved our recently introduced Bayesian transposable element ancestral reconstruction method to incorporate automated alignment and be more computationally efficient. We then used it to reconstruct the relationships amo...

Topics

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• Alu Elements
• Evolution, Molecular
• Genetic Variation
• Genome, Human
• HeLa Cells
• Models, Genetic
• Models, Molecular
• Retroelements

Identifiers and source

Literature Corpus work

a5b7da7a-cdb5-5fa9-99c8-c80fe6ece035

DOI

10.1101/094326