Article

Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells

2025-10-21

Abstract excerpt

In both neonates and adults, the presence of malignancy-associated mutations in peripheral blood (PB) correlates with an elevated risk of future neoplastic transformation, with certain mutations, such as KMT2A rearrangements, exhibiting near-complete penetrance. If feasible, pre-malignant screening could enable early intervention and even disease prevention. However, nucleic acid sequencing- and hybridization-bas...

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Literature Corpus work: de5590fa-21c6-5b9f-b16c-5fdc7a155128
DOI: 10.1101/2025.10.20.682949

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