Article

Pomalidomide enhances CAR-T cell therapeutic efficacy and Remodels Immune Microenvironment in Lymphoid Malignancies

2025-05-08

Abstract excerpt

<title>Abstract</title> Background Despite the remarkable efficacy of Chimeric Antigen Receptor T-cell (CAR-T) therapy in hematological malignancies, challenges including limited persistence and T cell exhaustion hinder long-term responses. Pomalidomide, an immunomodulatory drug, shows potential to synergize with CAR-T therapy, yet its mechanistic basis remains unclear. Methods We performed CCK8, LDH, qPCR...

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Literature Corpus work: de4c3c0f-e993-5dcc-af99-e495f6ef2eb4
DOI: 10.21203/rs.3.rs-6571044/v1

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