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Profound CD4+ T-Cell Reprogramming by Melphalan-Driven Oxidative Stress in High-Risk Multiple Myeloma

2026-06-11

Abstract excerpt

T cell-based immunotherapies have become central to the treatment of multiple myeloma (MM), yet their efficacy depends on the functionality of endogenous T cells. How cumulative treatment exposure, particularly high-dose melphalan, together with disease-intrinsic high-risk features shapes T-cell composition and immune competence remains incompletely understood. Here, we analyzed T cell composition and function in...

Identifiers and source

Literature Corpus work
4cf4aba2-0804-5f21-893f-9b1e1c0c5e73
DOI
10.64898/2026.06.08.730835
Open publication

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Profound CD4+ T-Cell Reprogramming by Melphalan-Driven Oxidative Stress in High-Risk Multiple MyelomaDOI 10.64898/2026.06.08.730835
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