Article

FAPα-positive fibroblasts in expert-reviewed colorectal hyperplastic polyps identify patients at increased risk of metachronous adenoma: a retrospective cohort study

2026-07-04

Abstract excerpt

<h4>Aims</h4> Serrated lesions contribute substantially to colorectal cancer (CRC), while routine management of small distal hyperplastic polyps (HPs) assumes low risk. Surveillance guidelines nevertheless incorporate uncertainty at the HP/SSL interface and recommend shortened intervals for large serrated lesions. (3,4) We tested whether fibroblast activation protein-α (FAPα) expression by stromal fibroblasts wit...

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Literature Corpus work: de29b12e-e437-557a-ae4b-9afb4206374b
DOI: 10.64898/2026.07.02.26357112

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