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Article

TGFβ-Responsive Stromal Activation Occurs Early in Serrated Colorectal Carcinogenesis.

International journal of molecular sciences - 24 Apr 2024

Tsumuraya Hideaki, Okayama Hirokazu, Katagata Masanori, Matsuishi Akira, Fukai Satoshi, Ito Misato, Sakamoto Wataru, Saito Motonobu, Momma Tomoyuki, Nakajima Shotaro, Mimura Kosaku, Kono Koji

Abstract excerpt

Activated TGFβ signaling in the tumor microenvironment, which occurs independently of epithelial cancer cells, has emerged as a key driver of tumor progression in late-stage colorectal cancer (CRC). This study aimed to elucidate the contribution of TGFβ-activated stroma to serrated carcinogenesis, representing approximately 25% of CRCs and often characterized by oncogenic BRAF mutations. We used a transcriptional...

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Identifiers

PMID: 38731846
DOI: 10.3390/ijms25094626
PMCID: PMC11083568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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