Article

SOX9 Expression in Colorectal Adenomas Improves Surveillance Colonoscopy Risk Stratification in a Bowel Screening Population

2024-06-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Adenomas are known precursors to colorectal cancer (CRC). Current UK post-polypectomy surveillance guidelines use polyp size, numbers, and histology to stratify the risk of patients developing metachronous polyps or CRC. However, these risk guidelines suffer from poor predictive value, often leading to under/over surveillance. <h4>Design</h4> Adenomas removed from 1257 pati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3721456c-cd80-56c0-807e-9b58fb6c2b57
DOI: 10.1101/2024.06.28.24309576

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SOX9 Expression in Colorectal Adenomas Improves Surveillance Colonoscopy Risk Stratification in a Bowel Screening PopulationDOI 10.1101/2024.06.28.24309576Read

Classical driver mutations are not associated with metachronous lesion risk in patients undergoing post-polypectomy surveillance following removal of conventional adenomas in a bowel screening settingSemantic proximity Read

Novel adenoma-immune phenotypes are associated with risk of metachronous polyps and colorectal cancer in a bowel screening cohortSemantic proximity Read

Original research: Impact of surveillance colonoscopy on colorectal cancer incidence and mortality in Lynch syndrome - a national observational cohort study of patients in the English NHS 2010-2022Semantic proximity Read

The somatic mutation landscape of premalignant colorectal adenoma.Semantic proximity Read

Endoscopic surveillance for colorectal cancer and its precursor lesions in Lynch syndrome; time for some policy shifts?Semantic proximity Read

Using colorectal cancer screening evidence to stratify for personal patient risk among those with a family history of colorectal cancer: a 42-year cohort studySemantic proximity Read

Diagnostic value of new combination of methylated Septin9 with LMR in adenomatous polyps and stage I to IV colorectal cancerSemantic proximity Read

KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia.Semantic proximity Read

FAPα-positive fibroblasts in expert-reviewed colorectal hyperplastic polyps identify patients at increased risk of metachronous adenoma: a retrospective cohort studySemantic proximity Read

Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2Semantic proximity Read

Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size.Semantic proximity Read

The Screening Value of Septin9, SDC2, and BCAT1 Triple Gene Methylation Detection Combined with Colonoscopy for Early Colorectal CancerSemantic proximity Read