Article

Tie2 signaling in the tumor microenvironment orchestrates breast cancer cell dissemination through TMEM doorways

2026-04-29

Abstract excerpt

During breast cancer metastasis, tumor cells migrate toward intratumoral blood vessels and intravasate through stable structures known as TMEM (Tumor Microenvironment of Metastasis) doorways. TMEM doorways, composed of a Mena-expressing tumor cell, a Tie2 hi /VEGF hi macrophage, and an endothelial cell, are clinically validated prognostic markers of distant metastasis in breast cancer and represent the exclusive...

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Literature Corpus work: 69fa02fa-0c4f-573b-9132-a0bfbac81f27
DOI: 10.64898/2026.04.26.720938

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