Article

Loss of NKX2-1 predisposes thyroid to neoplasm development through regulation of oxidative stress

2026-08-27

Abstract excerpt

Many factors including ionizing radiation and iodine deficiency are known to increase thyroid carcinogenesis risk. Our dataset analysis of The Cancer Genome Atlas (TCGA) showed that lower mRNA expression of NK2 homeobox 1 (NKX2-1) transcription factor, a master regulator of genesis, homeostasis, and function of thyroid, is linked to poor prognosis of papillary thyroid cancer patients. Here we provide the findings...

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Literature Corpus work: de0b6572-e0e0-5ab6-be5b-f9429efcd502
DOI: 10.64898/2026.08.26.746581

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