NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cells.

doi:10.7150/ijbs.123980

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Article

NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cells.

International journal of biological sciences - 1 Jan 2026

Radom Mickaëlle, Buffet Camille, Cazarin Juliana, Harinquet Marylin, de Faria Caroline Coelho, Brayé Floriane, Nobre Catline, Aglave Marine, Mesloub Yasmina, Dayris Thibault, Droin Nathalie, Godefroy Karine, Bani Mohamed-Amine, Ghuzlan Abir Al, Leboulleux Sophie, Lamartina Livia, Dupuy Corinne

Abstract excerpt

Radioiodine (RAI) therapy, used for treating differentiated thyroid cancers (DTCs), hinges on the functional expression of the sodium-iodide symporter (NIS). However, up to 60% of papillary thyroid carcinomas, the most common DTC subtype, harbor BRAFV600E mutations, which are strongly associated with reduced NIS expression, impaired RAI uptake, and poor differentiation scores. For patients with RAI-refractory, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 41694580
DOI: 10.7150/ijbs.123980
PMCID: PMC12905579

Genes

NOX4
MSH2
MSH6
DNMT1
OGG1
PAX8
BRAF

Provenance

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