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Article

Thyroid transcription factors in development, differentiation and disease.

Nature reviews. Endocrinology - 1 Jan 2015

Fernández Lara P, López-Márquez Arístides, Santisteban Pilar

Abstract excerpt

Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX, has considerably advanced our understanding of thyroid development, congenital thyroid disorders and thyroid cancer. The TTFs are fundamental to proper formation of the thyroid gland and for maintaining the functional differentiated state of the adult thyroid; however, they are not individually required for precursor cell...

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Source

Identifiers

PMID: 25350068
DOI: 10.1038/nrendo.2014.186

Genes

FOXE1
HHEX
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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