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Article

NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells.

BMC cancer - 2 May 2018

Penha Ricardo Cortez Cardoso, Buexm Luisa Aguirre, Rodrigues Fabiana Resende, de Castro Taciana Padilha, Santos Maria Carolina S, Fortunato Rodrigo Soares, Carvalho Denise P, Cardoso-Weide Luciene C, Ferreira Andrea C F

Abstract excerpt

BACKGROUND: NKX2.5 is a transcription factor transiently expressed during thyroid organogenesis. Recently, several works have pointed out the oncogenic role of NKX2.5 in a variety of tumors. We therefore hypothesized that NKX2.5 could also play a role in thyroid cancer. METHODS: The validation of NKX2.5 expression was assessed by immunohistochemistry analysis in a Brazilian case series of 10 papillary thyroid...

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Identifiers

PMID: 29716526
DOI: 10.1186/s12885-018-4399-1
PMCID: PMC5930850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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