Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands.

PloS one - 15 Oct 2010

Abu-Khudir Rasha, Paquette Jean, Lefort Anne, Libert Frederick, Chanoine Jean-Pierre, Vassart Gilbert, Deladoëy Johnny

Abstract excerpt

BACKGROUND: Congenital hypothyroidism from thyroid dysgenesis (CHTD) is predominantly a sporadic disease characterized by defects in the differentiation, migration or growth of thyroid tissue. Of these defects, incomplete migration resulting in ectopic thyroid tissue is the most common (up to 80%). Germinal mutations in the thyroid-related transcription factors NKX2.1, FOXE1, PAX-8, and NKX2.5 have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Profiling

Share to Genomics

Share to Thyroid Gland

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20976176
DOI: 10.1371/journal.pone.0013420
PMCID: PMC2955549

Genes

FOXE1
FRZB
HHEX
PAX8
SFRP2
TXNIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands.PMID 20976176Read ↗

Demonstration of Autosomal Monoallelic Expression in Thyroid Tissue Assessed by Whole-Exome and Bulk RNA Sequencing.Semantic proximity Read ↗

Molecular Genetics of Thyroid Dysgenesis: Established and Emerging ContributorsSemantic proximity Read ↗

Thyroid transcription factors in development, differentiation and disease.Semantic proximity Read ↗

Somatic mutations are not observed by exome sequencing of lymphocyte DNA from monozygotic twins discordant for congenital hypothyroidism due to thyroid dysgenesis.Semantic proximity Read ↗

Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations.Semantic proximity Read ↗

GWAS of thyroid dysgenesis identifies a risk locus at 2q33.3 linked to regulation of Wnt signaling.Semantic proximity Read ↗

Phenotypic Variability of Patients With PAX8 Variants Presenting With Congenital Hypothyroidism and Eutopic Thyroid.Semantic proximity Read ↗

ENDOCRINE TUMOURS: Advances in the molecular pathogenesis of thyroid cancer: lessons from the cancer genome.Semantic proximity Read ↗

Genetic analysis of the <i>PAX8</i> gene in children with congenital hypothyroidism and dysgenetic or eutopic thyroid glands: identification of a novel sequence variantSemantic proximity Read ↗

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factorsSemantic proximity Read ↗

<i>PAX8</i>,<i>TITF1</i>, and<i>FOXE1</i>Gene Expression Patterns during Human Development: New Insights into Human Thyroid Development and Thyroid Dysgenesis-Associated MalformationsSemantic proximity Read ↗

Genomic and epigenomic profile of thyroid cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.