Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.

International journal of molecular sciences - 21 Jan 2026

Ji Ren-Lei, Zheng Huifei Sophia, Wilson Alan E, Tao Ya-Xiong

Abstract excerpt

Melanocortin-2 receptor accessory protein 2 (MRAP2) is essential for the intricate regulation of energy balance. Although rare MRAP2 variants have been reported in obese individuals, their overall impact on human obesity risk remains uncertain because previous studies were small, heterogeneous, and often lacked systematic functional characterization. To address this gap, we conducted a comprehensive systematic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Obesity

Source

Open in PubMed Open full text

Identifiers

PMID: 41596694
DOI: 10.3390/ijms27021051
PMCID: PMC12841619

Genes

MRAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.PMID 41596694Read ↗

Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene.Semantic proximity Read ↗

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.Semantic proximity Read ↗

Updates on Monogenic Obesity in a Multifactorial Disease.Semantic proximity Read ↗

Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathwaysSemantic proximity Read ↗

Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways.Semantic proximity Read ↗

The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population.Semantic proximity Read ↗

The expanding landscape of genetic causes of obesity.Semantic proximity Read ↗

Updates on Rare Genetic Variants, Genetic Testing, and Gene Therapy in Individuals With Obesity.Semantic proximity Read ↗

The genetics of obesity: aetiology, prevention and therapy.Semantic proximity Read ↗

Syndromic and Nonsyndromic Obesity: Underlying Genetic Causes in Humans.Semantic proximity Read ↗

Genetic Insights into Severe Obesity: A Case Study of MC4R Variant Identification and Clinical ImplicationsSemantic proximity Read ↗

Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.