Article

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

2023-03-16

Abstract excerpt

Conventional protein kinase C (PKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations identified in neurodegeneration. PKC with impaired autoinhibition is removed from the cell by quality-control mechanisms to prevent accumulation of aberrantly active enzyme. Here, we examine how a single residue in the C1A domain of...

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Literature Corpus work: ddd89efa-c41f-5866-a662-f4a8deab5aec
DOI: 10.1101/2023.03.16.532226

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