Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

doi:10.1042/BCJ20220397

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Article

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

The Biochemical journal - 30 Aug 2023

Jones Alexander C, Kornev Alexandr P, Weng Jui-Hung, Manning Gerard, Taylor Susan S, Newton Alexandra C

Abstract excerpt

Conventional protein kinase C (cPKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations identified in neurodegeneration. PKC with impaired autoinhibition is removed from the cell by quality-control mechanisms to prevent the accumulation of aberrantly active enzyme. Here, we examine how a highly conserved residue in...

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PMID: 37551632
DOI: 10.1042/BCJ20220397
PMCID: PMC10586763

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