Article

Enhanced Activity of Alzheimer Disease-associated Variant of Protein Kinase Cα Drives Cognitive Decline

2021-09-20

Abstract excerpt

<title>Abstract</title> <p>Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are generally associated with cancer, gain-of-function variants in one isozyme, PKCα, are associated with Alzheimer’s disease (AD). Here we show that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6c83a8f-7cbf-5c10-8cef-7d91297239a7
DOI: 10.21203/rs.3.rs-894083/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhanced Activity of Alzheimer Disease-associated Variant of Protein Kinase Cα Drives Cognitive DeclineDOI 10.21203/rs.3.rs-894083/v1Read

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse modelSemantic proximity Read

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.Semantic proximity Read

Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.Semantic proximity Read

Sex specific disruptions in Protein Kinase Cγ signaling in a mouse model of Spinocerebellar Ataxia Type 14Semantic proximity Read

Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing AutoinhibitionSemantic proximity Read

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.Semantic proximity Read

Sex-specific disruptions in PKCγ signaling in a mouse model of spinocerebellar ataxia type 14.Semantic proximity Read

PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's diseaseSemantic proximity Read

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.Semantic proximity Read

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.Semantic proximity Read

Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer’s disease using a recessive mode of inheritanceSemantic proximity Read

Single-residue mutation in protein kinase C toggles between cancer and neurodegenerationSemantic proximity Read