Article

Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics

2025-07-07

Abstract excerpt

ABSTRACT Immune checkpoints, the key gatekeepers of immune homeostasis, have become the central targets of modern cancer immunotherapy. These regulatory pathways, composed of co‐suppressive and co‐stimulatory molecules, enable the immune system to distinguish between self and non‐self while preventing excessive tissue damage. However, tumor cells strategically block these protective mechanisms through aberrant exp...

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Literature Corpus work: d6a6bf16-0787-5cc7-8cf0-74c1b02bd177
DOI: 10.1002/mog2.70030

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