Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and κ loci and expression of fully human antibodies

18 Jan 2000

Abstract excerpt

The use of a human chromosome or its fragment as a vector for animal transgenesis may facilitate functional studies of large human genomic regions. We describe here the generation and analysis of double trans-chromosomic (Tc) mice harboring two individual human chromosome fragments (hCFs). Two transmittable hCFs, one containing the Ig heavy chain locus (IgH, approximately 1.5 Mb) and the other the kappa light...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10639146
DOI: 10.1073/pnas.97.2.722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and κ loci and expression of fully human antibodiesPMID 10639146Read ↗

Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin lociSemantic proximity Read ↗

Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin lociSemantic proximity Read ↗

Comparative analysis of trans-chromosomic rodent models reveals improved somatic hypermutation and class-switch recombination in ratsSemantic proximity Read ↗

Antibody Repertoires of Four- and Five-Feature Translocus Mice Carrying Human Immunoglobulin Heavy Chain and κ and λ Light Chain Yeast Artificial ChromosomesSemantic proximity Read ↗

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice.Semantic proximity Read ↗

Antigen-specific human antibodies from mice comprising four distinct genetic modifications.Semantic proximity Read ↗

Human Antibodies from Transgenic MiceSemantic proximity Read ↗

High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat CH RegionSemantic proximity Read ↗

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.Semantic proximity Read ↗

Production of Human Monoclonal and Polyclonal Antibodies in TransChromo AnimalsSemantic proximity Read ↗

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies.Semantic proximity Read ↗

Human Antibody Production in Transgenic AnimalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.